Originally published by GreenMedInfo blog, May 30, 2014; Used with permission.
A new vaccine study published in Molecular and Genetic Medicine is bringing to the forefront the disturbing connection between the dramatic expansion in the quantity of routine childhood vaccines administered and a corresponding increase in inflammation-associated disorders.
Titled, "Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Emphasis on Explaining the Recent Accelerations in the Risk of Prediabetes and other Immune Mediated Diseases," the study argues that vaccine-induced immune overload is a driving factor in a number of rapidly accelerating childhood epidemics including:
- Type 1 diabetes
- Food allergies
- Many autoimmune diseases
- Type 2 diabetes
- Non-alcoholic fatty liver disease (NAFL)
- Metabolic disease.
The paper sought to provide a theory of vaccine induced immune overload to explain many observations about the changes in the epidemics. The fundamental problem, according to the study, is that vaccinology assumes a "one size fits all" approach that results in the majority of the vaccine recipients having overstimulated immune systems:
"One major problem with vaccines is the concept of one size fits all. Package inserts of almost all vaccines recommend a dose based on age. In order for a vaccine to be a commercial success it is expected to induce a protective immune response in well over 90% of children. In order for this to happen a dose, based on age, must stimulate a protective immune response in those with the weakest immune system. In the process of doing this, the other 90% or more of children have their immune system over stimulated. The process of over stimulating the immune system time and time again increases the risk of inflammatory diseases like autoimmune diseases, and allergies which cause even more inflammation."
The result of the over stimulated state of the body following vaccination varies, but depends entirely on bio-individuality, namely, the unique physiological response an individual has to inflammation. The inflammatory cascade has other adverse downstream effects:
"Inflammation causes the release of cytokines which can trigger autoimmune diseases but also stimulate cortisol production, the major negative feedback loop of the immune system. According to the theory inflammation induced cortisol production varies based on race  which can be explained by the presence of genes that alter cortisol production. Individuals who produce a lot of cortisol in response to inflammation have a tendency to develop a Cushingoid like response that includes obesity, type 2 diabetes/insulin resistance, hypertension, and dyslipidemia which is called metabolic syndrome."
As the dominant meme perpetuated by stakeholders in the vaccine agenda over the past 15 years has been 'the more vaccines the better,' today's vaccine schedule is loaded to the hilt with vaccines, each new addition increasing with mathematical certainty the chances of immune overload:
"Since 1999 the routine pediatric immunization schedule [9,10] increased by 80 vaccines. This number is derived by the fact that multivalent vaccines contain specific vaccines to each separate strain. The following have been added, pneumococcus (13 valent), meningococcus (4 valent), human papilloma virus (4 valent), hepatitis A (1 valent), rotatavirus (4 additional valent), influenza (3 valent per year x 18 years=54)."
The study provided in depth explanations of the various ways in which vaccine induced immune over stimulation may contribute to chronic diseases such as type 1 diabetes, obesity, and NAFL, but the proposed link with autism is most conspicuous, considering it is a highly taboo topic to link vaccine exposures with autism spectrum disorder. The lead author of the study referenced a previous study he published last year (2013) titled "Prevalence of Autism is Positively Associated with the Incidence of Type 1 Diabetes, but Negatively Associated with the Incidence of Type 2 Diabetes, Implication for the Etiology of the Autism Epidemic Molecular and Genetic Medicine," wherein is described research linking the prevalence of type 1 diabetes with autism, suggesting their etiologies are related, including a mention of the possible role of vaccines in contributing to these simultaneous epidemics. Clearly if vaccines are capable of over stimulating the immune system and/or breaking immunological self-tolerance, this could be expressed in a wide range of ways: the immune system could attack the insulin producing beta cells in the pancreas (type 1 diabetes) or the brain (autism). The permutations and effects on health are actually quite endless.
The author pointed out that the theory of vaccine-induced autoimmunity has been exceedingly difficult to prove because both post-marketing epidemiological surveillance studies and prospective controlled trials of vaccines performed for licensure are either too small, too short in duration or inappropriately controlled (use other vaccines as controls) to appropriately study the relationship between vaccines and these epidemics.
The author also points out that "While it would be ideal to have more clinical trial data, industry and government have been reluctant to provide such information. However, conclusions regarding toxicity of many agents including cigarettes and asbestos were made without clinical trial data. The author believes that the sum of the data described and relationship."
We feel the author is correct to raise the cautionary flag. This is not a strictly academic issue, as the present and future health of our children is on the line. If the expansive pediatric immunization schedule is resulting in the over stimulation and dysregulation of childhood immunity, explaining the mystery behind the atrocious and seemingly "idiopathic" epidemic of autism, the approach must immediately be suspended and reassessed for safety with appropriately controlled trials (non-vaccine controls) to provide the necessary evidence long lauded as the basis and justification for vaccination versus nutritional optimization, sanitation, hygiene and plant-based medicine as the first strategic line of defense for the prevention of infectious disease. Anything less than this is pseudo-scientific and clearly violates informed consent.